The CZ 110 is based on a barrel short recoil principle. Barrels locking principle is similar to the Browning HP Self-loading Pistol. The only safety-lock is an automatic firing pin. Pistol is mostly intended for double-action usage. However there is ability to use a single-action mode if required to make an accurate first shot. It makes able to carry pistol with a cartridge loaded in the barrels channel. The CZ 110 has a barrels channel load indicator. It is also fitted with a frame mounted decocker.
It has a polymer frame and handle, however slide is made from steel. Trigger guard allows to execute fire from both hands.